专利名称：METHOD AND DEVICE FOR CREATING
MICRO-ARRAYS
发明人：LEIGHTON, STEPHEN B.申请号：EP00970705申请日：20001010公开号：EP1325108A4公开日：20050831
摘要：A method and device are provided for simultaneously creating a plurality ofidentical micro-arrays of biological samples. The invention utilizes a plurality ofsubstrates, each of which having a top side, a bottom side, and a pattern of through-holes. Each through-hole has a wider upper cross-section, a narrower lower cross-section,and a step or plateau formed in the transition area. When the substrates are stacked,through-holes are in registry and form tunnels extending through the stack of
substrates. Reagents of interest are caused to flow through the tunnels and deposit onthe step or plateau area. A barrier layer may be provided to prevent leak-throughbetween neighboring holes. After the desired reagents have been deposited, thesubstrates are separated. In this manner a series of micro-arrays, each capable ofcontaining hundreds or thousands of biological samples such as cDNA fragments, isformed simultaneously.
申请人：LEIGHTON, STEPHEN B.
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