专利名称:Enhancement of transdermal drug delivery
using monoalkyl phosphates and otherabsorption promoters
发明人:Ooi Wong,Thuytien N. Nguyen申请号:US08/163817申请日:19931208公开号:US05358715A公开日:19941025
摘要:Pharmaceutical formulations, transdermal drug delivery devices, and methodsof drug delivery using the formulations and devices of the invention are disclosed whichmake it possible to enhance the rate of transdermal drug delivery of pharmaceuticallyactive compounds and in particular molsidomine. The rate of drug delivery is increased byusing absorption promoters which include monoalkyl phosphates and salts thereof aloneor in combination with other absorption promoters such as polyhydroxyl esters,longchain fatty acids, polyhydroxyl alcohols and terpenes. Particular combinations ofmonoalkyl phosphates with one or more additional absorption promoters providessynergistic effects with respect to enhancing the rate of drug delivery of certainpharmaceutically active drugs such as molsidomine.
申请人:CYGNUS THERAPEUTIC SYSTEMS
代理机构:Morrison & Foerster
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