专利名称：METHODS OF IDENTIFYING
IMMUNOREGULATORY AGENTS,
IMMUNOREGULATORY AGENTS, AND USESTHEREOF
发明人：MORIMOTO, Chikao,OHNUMA, Kei申请号：EP04808195.4申请日：20041228公开号：EP1709450A2公开日：20061011
摘要：The present invention provides methods of identifying a substance that down-regulates or up-regulates an immune response and kits used for the identificationmethods. A method of this invention comprises detecting a substance that inhibits orenhances the interaction between CD26 and caveolin-1. Another method comprisesdetecting a substance that inhibits or enhances the interaction between caveolin-1 andTollip. Still another method comprises detecting a substance that inhibits or enhancesthe interaction among caveolin-1, Tollip, and IRAK-1. The present invention also relatesto immunoregulatory agents comprising a substance that down-regulates an immuneresponse, such as siRNA against caveolin-1 or Tollip. The invention further providesimmunoregulatory agents comprising a substance that up-regulates an immuneresponse. These agents are useful for treating inflammatory diseases, autoimmunediseases, or other immune-mediated disorders.
申请人：TOUDAI TLO, Ltd.
地址：3-1, Hongo 7-chome, Bunkyo-ku Tokyo 113-0033 JP
国籍：JP
代理机构：Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät
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