专利名称：ANTIFUNGAL ANTIBIOTIC OBTAINED FROM
BASIDIOMYCETE OUDEMANSIELLA MUCIDAAND PROCESS OF MAKING THE SAME
发明人：MUSILEK V,CS申请号：US3716635D申请日：19700804公开号：US3716635A公开日：19730213
摘要：1,163,910. Antifungal antibiotic; mucidin. CESKOSLOVENSKA AKADEMIE VED. 14Dec., 1966 [17 Dec., 1965], No. 55909/66. Heading C2A. A fermentation broth containing anew antifungal antibiotic mucidin is obtained by growing the basidiomycete
Ondemannsiella mucida under aerobic conditions in a liquid growth medium containing asource of assimilable carbon and nitrogen and a mineral nutrient salt and preferably bysubmerged cultivation. The pH is 3 to 7 and preferably 5.5 to 6.0, the temperature is 18‹to 25‹ C. and the duration is 6 to 8 days. The clarified broth or separated mycelium maybe extracted with a solvent such as ethyl ether, ethanol, ethyl acetate or chloroform. Thesolvent is removed and the extract dissolved in a pharmaceutical solvent to produce apharmaceutical composition for topical use. Mucidin is active against fungi but notbacteria; it shows absorption peaks in the U.V. region at 205, 211, 223, 229, 237, 284, 292,299 and 312 mÁ.
申请人：CESKOSLOVENSKA AKADEMIE VED,CS
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