STACKED, PATTERNED BIOMATERIALS ANDOR TISSUE ENGI

专利名称：STACKED, PATTERNED BIOMATERIALS

AND/OR TISSUE ENGINEERING SCAFFOLDS

发明人：VRANA, Nihal Engin,ZORLUTUNA, Pinar申请号：EP07748778.3申请日：20070319公开号：EP2137241A1公开日：20091230

摘要：Stacked, lamellar constructs comprised of, synthetic or natural, polymericmembrane structures which are brought together to form 3D scaffolds for biomaterialand guided tissue engineering applications have been developed. Each layer can have 2Dor 3D nano and micro topographical features similar to or different than each other whichcan be arranged during the construction of each lamellae and their orientation can beadjusted during construction phase of the 3D structure. Such a construct was utilized inthe development of an artificial cornea with human primary cells, in which patternedsurface of the components of the lamellar structure mimics the oriented collagenstructure inherent in natural cornea. Similar exploitation of the 3D patterned structurecan be made for tissues where aligned ECM architecture is crucial, such as ligaments,bone, tendon, skin.

申请人：Hasirci, Vasif

地址：ODTU Biyolojik Bilimler Bölümü Biyoteknoloji Arastirma Birimi Ogretim Uyesi06531 Ankara TR

国籍：TR

代理机构：Walcher, Armin

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