IMMUNOGENIC COMPOSITIONS AND A PROCESS FOR PRODUCI

专利名称：IMMUNOGENIC COMPOSITIONS AND A

PROCESS FOR PRODUCING SAME

发明人：DRUMMER, Heidi,POUMBOURIOS, Pantelis申请号：EP14765209.3申请日：20140317公开号：EP2970919A1公开日：20160120

摘要：The present invention provides a modified HIV envelope glycoprotein (Env)antigen or a lipid containing vehicle comprising same. The Env antigen comprises one of asecond site suppressor mutation in residue 674 of the membrane proximal ectodomainregion (MPER) of HIV gp41; a second site suppressor mutation which ablates a

glycosylation site in the variable region (V1) region of gp120; or a second site suppressormutation ablating a glycosylation site in the V1 region of gp120 and a second sitesuppressor mutation in residue 674 of the MPER of HIV gp41. It is preferred that thelipid containing vehicle is a HIVLP.

申请人：THE MACFARLANE BURNET INSTITUTE FOR MEDICAL RESEARCH AND PUBLICHEALTH LTD

地址：85 Commercial Road Melbourne VIC 3004 AU

国籍：AU

代理机构：Care, Alison

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