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Pharmaceutical compounds, preparation, use and int

2023-11-25 来源:爱问旅游网
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专利名称:Pharmaceutical compounds, preparation,

use and intermediates therefor and theirpreparation

发明人:Lowe, Lawrence Alfred,Wilkinson,

Samuel,Smith, Terence William

申请号:EP83101069.9申请日:19830204公开号:EP0085963B1公开日:19870121

摘要:Novel peptides of formula (I) X-Tyr-X2-Gly-Phe(4NO2)-Pro-NH2 (I) and saltsthereof, wherein X is hydrogen or an amidino group and X2 is a radical selected from D-S-methylmethionyl and D-arginyl, have a selectively peripheral analgesic effect whenadministered to mammals. The compounds also exhibit antidiarrhoeal and antitussiveactivity and may thus be used in human or veterinary medicine for the relief or preventionof pain, for the treatment of diarrhoea or dysentery and for the suppression of cough.

申请人:THE WELLCOME FOUNDATION LIMITED

地址:Unicorn House 160 Euston Road P.O. Box 129 London NW1 2BP GB

国籍:GB

代理机构:Sandmair, Kurt, Dr. Dr.

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